Spaced administration of PA32540 and clopidogrel results in greater platelet inhibition than synchronous administration of enteric-coated aspirin and enteric-coated omeprazole and clopidogrel by Gurbel Paul A, Bliden Kevin P, Fort John G, Jeong Young-Hoon, Shuldiner Alan, Chai Sumbul, Gesheff Tania, Antonino Mark, Gesheff Martin, Zhang Ying, Tantry Udaya S in American heart journal (2013).

[PMID: 23351820] PubMed


A common regimen for patients requiring dual-antiplatelet therapy who are at risk for gastrointestinal complications is the synchronous administration of enteric-coated (EC) aspirin, a proton pump inhibitor, and clopidogrel, although proton pump inhibitors have the potential for pharmacodynamic interaction with clopidogrel. Spaced administration of a clopidogrel and a single-tablet formulation of aspirin and immediate-release omeprazole (PA32540) was considered as an alternative that might reduce this potential pharmacodynamic interaction.

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