HLA-DQ strikes again: Genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults by Lasky-Su J, Himes B E, Raby B A, Klanderman B J, Sylvia J Senter, Lange C, Melen E, Martinez F D, Israel E, Gauderman J, Gilliland F, Sleiman P, Hakonarson H, Celedón J C, Soto-Quiros M, Avila L, Lima J J, Irvin C G, Peters S P, Boushey H, Chinchilli V M, Mauger D, Tantisira K, Weiss S T, and for the SHARP investigators in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2012).

[PMID: 23181788] PubMed


Asthma is a common chronic respiratory disease in children and adults. An important genetic component to asthma susceptibility has long been recognized, most recently through the identification of several genes (e.g., ORMDL3, PDE4D, HLA-DQ, and TLE4) via genome-wide association studies.

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