CYP2A6 and CYP2B6 genetic variation and its association with nicotine metabolism in South Western Alaska Native people by J Binnington Matthew, Zhu Andy Z X, Renner Caroline C, Lanier Anne P, Hatsukami Dorothy K, Benowitz Neal L, Tyndale Rachel F in Pharmacogenetics and genomics (2012).

[PMID: 22569203] PubMed


Alaska Native (AN) people have a high prevalence of tobacco use and associated morbidity and mortality when compared with the general USA population. Variations in the CYP2A6 and CYP2B6 genes, encoding enzymes responsible for nicotine metabolic inactivation and procarcinogen activation, have not been characterized in AN and may contribute toward the increased risk.

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