Protease activated receptor-1 (PAR-1) mediated platelet aggregation is dependant on clopidogrel response by Kreutz Rolf P, Breall Jeffrey A, Kreutz Yvonne, Owens Janelle, Lu Deshun, Bolad Islam, von der Lohe Elisabeth, Sinha Anjan, Flockhart David A in Thrombosis research (2012).

[PMID: 22459907] PubMed


Clopidogrel inhibits ADP mediated platelet aggregation through inhibition of the P2Y12 receptor by its active metabolite. Thrombin induces platelet aggregation by binding to protease activated receptor-1 (PAR-1), and inhibition of PAR-1 has been evaluated in patients treated with clopidogrel to reduce ischemic events after acute coronary syndromes. Residual PAR-1 mediated platelet aggregation may be dependent on extent of clopidogrel response.

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