μ-Opioid receptor availability in the amygdala is associated with smoking for negative affect relief
Gold Allison B,
Wileyto E Paul,
Blendy Julie A,
The perception that smoking relieves negative affect contributes to smoking persistence. Endogenous opioid neurotransmission, and the μ-opioid receptor (MOR) in particular, plays a role in affective regulation and is modulated by nicotine.