Characterization of genome-wide association-identified variants for atrial fibrillation in African Americans by Delaney Jessica T, Jeff Janina M, Brown Nancy J, Pretorius Mias, Okafor Henry E, Darbar Dawood, Roden Dan M, Crawford Dana C in PloS one (2012).

[PMID: 22384221] PubMed


Despite a greater burden of risk factors, atrial fibrillation (AF) is less common among African Americans than European-descent populations. Genome-wide association studies (GWAS) for AF in European-descent populations have identified three predominant genomic regions associated with increased risk (1q21, 4q25, and 16q22). The contribution of these loci to AF risk in African American is unknown.

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