Association of HLA-B*5801 allele and allopurinol-induced Stevens Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis by Somkrua Ratchadaporn, Eickman Elizabeth E, Saokaew Surasak, Lohitnavy Manupat, Chaiyakunapruk Nathorn in BMC medical genetics (2011).

[PMID: 21906289] PubMed


Despite some studies suggesting a possible association between human leukocyte antigen, HLA-B*5801 and allopurinol induced Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN), the evidence of association and its magnitude remain inconclusive. This study aims to systematically review and meta-analyze the association between HLA-B*5801 allele and allopurinol-induced SJS/TEN.

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