Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption by Cornelis Marilyn C, Monda Keri L, Yu Kai, Paynter Nina, Azzato Elizabeth M, Bennett Siiri N, Berndt Sonja I, Boerwinkle Eric, Chanock Stephen, Chatterjee Nilanjan, Couper David, Curhan Gary, Heiss Gerardo, Hu Frank B, Hunter David J, Jacobs Kevin, Jensen Majken K, Kraft Peter, Landi Maria Teresa, Nettleton Jennifer A, Purdue Mark P, Rajaraman Preetha, Rimm Eric B, Rose Lynda M, Rothman Nathaniel, Silverman Debra, Stolzenberg-Solomon Rachael, Subar Amy, Yeager Meredith, Chasman Daniel I, van Dam Rob M, Caporaso Neil E in PLoS genetics (2011).

[PMID: 21490707] PubMed


We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P¿=¿2.4×10(-19)), near AHR, and 15q24 (P¿=¿5.2×10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.

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