Pharmacogenetics: From Bench to Byte- An Update of Guidelines by Swen J J, Nijenhuis M, de Boer A, Grandia L, Maitland-van der Zee A H, Mulder H, Rongen G A P J M, van Schaik R H N, Schalekamp T, Touw D J, van der Weide J, Wilffert B, Deneer V H M, Guchelaar H-J in Clinical pharmacology and therapeutics (2011).

[PMID: 21412232] PubMed

Abstract

Currently, there are very few guidelines linking the results of pharmacogenetic tests to specific therapeutic recommendations. Therefore, the Royal Dutch Association for the Advancement of Pharmacy established the Pharmacogenetics Working Group with the objective of developing pharmacogenetics-based therapeutic (dose) recommendations. After systematic review of the literature, recommendations were developed for 53 drugs associated with genes coding for CYP2D6, CYP2C19, CYP2C9, thiopurine-S-methyltransferase (TPMT), dihydropyrimidine dehydrogenase (DPD), vitamin K epoxide reductase (VKORC1), uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1), HLA-B44, HLA-B*5701, CYP3A5, and factor V Leiden (FVL).

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Dosing Information

DPWG Guideline for abacavir and HLA-B
DPWG Guideline for acenocoumarol and CYP2C9
DPWG Guideline for acenocoumarol and VKORC1
DPWG Guideline for amitriptyline and CYP2D6
DPWG Guideline for aripiprazole and CYP2D6
DPWG Guideline for azathioprine and TPMT
DPWG Guideline for capecitabine and DPYD
DPWG Guideline for carvedilol and CYP2D6
DPWG Guideline for citalopram and CYP2C19
DPWG Guideline for clomipramine and CYP2D6
DPWG Guideline for clozapine and CYP2D6
DPWG Guideline for codeine and CYP2D6
DPWG Guideline for doxepin and CYP2D6
DPWG Guideline for escitalopram and CYP2C19
DPWG Guideline for esomeprazole and CYP2C19
DPWG Guideline for flecainide and CYP2D6
DPWG Guideline for fluorouracil and DPYD
DPWG Guideline for glimepiride and CYP2C9
DPWG Guideline for imipramine and CYP2D6
DPWG Guideline for mirtazapine and CYP2D6
DPWG Guideline for olanzapine and CYP2D6
DPWG Guideline for oxycodone and CYP2D6
DPWG Guideline for phenprocoumon and CYP2C9
DPWG Guideline for propafenone and CYP2D6
DPWG Guideline for sertraline and CYP2C19
DPWG Guideline for tacrolimus and CYP3A5
DPWG Guideline for tamoxifen and CYP2D6
DPWG Guideline for venlafaxine and CYP2D6
DPWG Guideline for voriconazole and CYP2C19
DPWG Guideline for zuclopenthixol and CYP2D6
Dutch Pharmacogenetics Working Group Guideline for atomoxetine and CYP2D6
Dutch Pharmacogenetics Working Group Guideline for clopidogrel and CYP2C19
Dutch Pharmacogenetics Working Group Guideline for duloxetine and CYP2D6
Dutch Pharmacogenetics Working Group Guideline for flupenthixol and CYP2D6
Dutch Pharmacogenetics Working Group Guideline for glibenclamide and CYP2C9
Dutch Pharmacogenetics Working Group Guideline for gliclazide and CYP2C9
Dutch Pharmacogenetics Working Group Guideline for haloperidol and CYP2D6
Dutch Pharmacogenetics Working Group Guideline for hormonal contraceptives for systemic use and F5
Dutch Pharmacogenetics Working Group Guideline for imipramine and CYP2C19
Dutch Pharmacogenetics Working Group Guideline for irinotecan and UGT1A1
Dutch Pharmacogenetics Working Group Guideline for lansoprazole and CYP2C19
Dutch Pharmacogenetics Working Group Guideline for mercaptopurine and TPMT
Dutch Pharmacogenetics Working Group Guideline for metoprolol and CYP2D6
Dutch Pharmacogenetics Working Group Guideline for moclobemide and CYP2C19
Dutch Pharmacogenetics Working Group Guideline for nortriptyline and CYP2D6
Dutch Pharmacogenetics Working Group Guideline for omeprazole and CYP2C19
Dutch Pharmacogenetics Working Group Guideline for pantoprazole and CYP2C19
Dutch Pharmacogenetics Working Group Guideline for paroxetine and CYP2D6
Dutch Pharmacogenetics Working Group Guideline for phenprocoumon and VKORC1
Dutch Pharmacogenetics Working Group Guideline for phenytoin and CYP2C9
Dutch Pharmacogenetics Working Group Guideline for rabeprazole and CYP2C19
Dutch Pharmacogenetics Working Group Guideline for ribavirin and HLA-B
Dutch Pharmacogenetics Working Group Guideline for risperidone and CYP2D6
Dutch Pharmacogenetics Working Group Guideline for tegafur and DPYD
Dutch Pharmacogenetics Working Group Guideline for thioguanine and TPMT
Dutch Pharmacogenetics Working Group Guideline for tolbutamide and CYP2C9
Dutch Pharmacogenetics Working Group Guideline for tramadol and CYP2D6