Nicotine metabolite ratio predicts smoking topography and carcinogen biomarker level by Strasser Andrew A, Benowitz Neal L, Pinto Angela G, Tang Kathy Z, Hecht Stephen S, Carmella Steve G, Tyndale Rachel F, Lerman Caryn E in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2011).

[PMID: 21212060] PubMed


Variability in smoking behavior is partly attributable to heritable individual differences in nicotine clearance rates. This can be assessed as the ratio of the metabolites cotinine and 3'-hydroxycotinine (referred to as the nicotine metabolism ratio; NMR). We hypothesized that faster NMR would be associated with greater cigarette puff volume and higher levels of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a carcinogen biomarker.

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