Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans by Hughes Laura B, Reynolds Richard J, Brown Elizabeth E, Kelley James M, Thomson Brian, Conn Doyt L, Jonas Beth L, Westfall Andrew O, Padilla Miguel A, Callahan Leigh F, Smith Edwin A, Brasington Richard D, Edberg Jeffrey C, Kimberly Robert P, Moreland Larry W, Plenge Robert M, Bridges S Louis in Arthritis and rheumatism (2010).

[PMID: 21120996] PubMed


Large-scale genetic association studies have identified >20 rheumatoid arthritis (RA) risk alleles among individuals of European ancestry. The influence of these risk alleles has not been comprehensively studied in African Americans. We therefore sought to examine whether these validated RA risk alleles are associated with RA risk in an African American population.

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