Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program by Jablonski Kathleen A, McAteer Jarred B, de Bakker Paul I W, Franks Paul W, Pollin Toni I, Hanson Robert L, Saxena Richa, Fowler Sarah, Shuldiner Alan R, Knowler William C, Altshuler David, Florez Jose C, Diabetes Prevention Program Research Group in Diabetes (2010).

[PMID: 20682687] PubMed


Genome-wide association studies have begun to elucidate the genetic architecture of type 2 diabetes. We examined whether single nucleotide polymorphisms (SNPs) identified through targeted complementary approaches affect diabetes incidence in the at-risk population of the Diabetes Prevention Program (DPP) and whether they influence a response to preventive interventions.

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