Functional variants in MBL2 are associated with type 2 diabetes and pre-diabetes traits in Pima Indians and the old order Amish by Muller Yunhua L, Hanson Robert L, Bian Li, Mack Janel, Shi Xiaolian, Pakyz Ruth, Shuldiner Alan R, Knowler William C, Bogardus Clifton, Baier Leslie J in Diabetes (2010).

[PMID: 20522590] PubMed


MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in insulin resistance and development of type 1 diabetes and gestational diabetes mellitus. To assess the role of MBL2 in diabetes susceptibility, this gene was analyzed in the Pima Indian population, which has a high prevalence of type 2 diabetes.

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