Vitamin E reduces cardiovascular disease in individuals with diabetes mellitus and the haptoglobin 2-2 genotype by Blum Shany, Vardi Moshe, Brown Jonathan B, Russell Allen, Milman Uzi, Shapira Chen, Levy Nina S, Miller-Lotan Rachel, Asleh Rabea, Levy Andrew P in Pharmacogenomics (2010).

[PMID: 20415560] PubMed


Individuals with both diabetes mellitus (DM) and the Haptoglobin (Hp) 2-2 genotype are at increased risk of cardiovascular disease. As the antioxidant function of the Hp 2-2 protein is impaired, we sought to test the pharmacogenomic hypothesis that antioxidant vitamin E supplementation would provide cardiovascular protection to Hp 2-2 DM individuals.

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