Efficacy and cardiac safety of adjuvant trastuzumab-based chemotherapy regimens for HER2-positive early breast cancer by Costa R B, Kurra G, Greenberg L, Geyer C E in Annals of oncology : official journal of the European Society for Medical Oncology / ESMO (2010).

[PMID: 20351072] PubMed


Trastuzumab-based adjuvant therapy has become the standard of care for human epidermal growth factor receptor-2 (HER2)-positive early breast cancer (EBC). Both anthracycline- and non-anthracycline-containing trastuzumab regimens are approved in the United States, but cardiotoxicity is increased with anthracycline-containing regimens.

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