Impact of the CYP2C19*17 Allele on the Pharmacokinetics of Omeprazole and Pantoprazole in Children: Evidence for a Differential Effect by Kearns Gregory L, Leeder J Steven, Gaedigk Andrea in Drug metabolism and disposition: the biological fate of chemicals (2010).

[PMID: 20223877] PubMed


The impact of the CYP2C19*17 allele on the pharmacokinetics of pantoprazole and omeprazole in previously studied children (n=40) was explored. When pantoprazole AUC was examined as a function of CYP2C19 genotype, a significantly lower AUC was observed for subjects identified as CYP2C19*1/*1 and *1/*17. For pantoprazole, a statistically significant relationship was observed between CYP2C19 genotype and both dose-corrected AUC (p<0.0001) and the apparent elimination rate constant (K(el); p=0.0012); no significant genotype-phenotype relationships were observed for omeprazole.

[ hide abstract ]

Discussed In Paper


Variant Annotations

Sign in to see variant annotations.

Rx Annotations

No dosing information annotated.