Association of the glutamate transporter gene SLC1A1 with atypical antipsychotics-induced obsessive-compulsive symptoms by Kwon Jun Soo, Joo Yeon Ho, Nam Hee Jung, Lim Meerae, Cho Eun-Young, Jung Myung Hun, Choi Jung-Seok, Kim Byungsu, Kang Do-Hyung, Oh Sohee, Park Taesung, Hong Kyung Sue in Archives of general psychiatry (2009).

[PMID: 19884611] PubMed


Several studies have indicated that atypical antipsychotics (AAP) induce obsessive-compulsive (OC) symptoms. Research exploring the mechanism of this phenomenon, however, has been extremely limited. Considering the indirect evidence of genetic control and difficulties in developing animal models and performing gene expression studies, genetic association studies could be an important approach to understanding the molecular mechanism of AAP-induced OC symptoms. The glutamate transporter gene SLC1A1, which was recently reported to be associated with obsessive-compulsive disorder (OCD), is a promising candidate gene for susceptibility to AAP-induced OC symptoms.

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