Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia by Schuhmacher Anna, Mössner Rainald, Quednow Boris B, Kühn Kai-Uwe, Wagner Michael, Cvetanovska Gabriela, Rujescu Dan, Zill Peter, Möller Hans-Jürgen, Rietschel Marcella, Franke Petra, Wölwer Wolfgang, Gaebel Wolfgang, Maier Wolfgang in Pharmacogenetics and genomics (2009).

[PMID: 19794330] PubMed


Among serotonin (5-HT) receptors, the 5-HT3 receptor is the only ligand-gated ion channel. 5-HT3 antagonists such as ondansetron and tropisetron may improve auditory gating and neurocognitive deficits in schizophrenic patients. Moreover, many antipsychotic drugs are antagonists at 5-HT3 receptors. However, the role of 5-HT3 receptor variants on response to antipsychotic drugs in schizophrenic patients is still unclear.

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