Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias by Norris Robin E, Adamson Peter C in Cancer chemotherapy and pharmacology (2010).

[PMID: 19784838] PubMed


Renewed interest in antifols for the treatment of childhood cancers has resulted from identification of novel antifols with broad spectrums of anti-cancer activity and from re-evaluation of the original clinical antifol, aminopterin. In this pre-clinical study we evaluated the in vitro activity of both traditional antifols (methotrexate, aminopterin) and novel antifols (pemetrexed, talotrexin) in childhood acute leukemias and lymphomas.

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