CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients by Kwara Awewura, Lartey Margaret, Sagoe Kwamena W C, Kenu Ernest, Court Michael H in AIDS (London, England) (2009).

[PMID: 19779319] PubMed


UDP-glucuronosyltransferase (UGT) 2B7 was recently identified as the main enzyme mediating efavirenz N-glucuronidation. In this study, we determined whether selected UGT2B7 polymorphisms could be used to enhance the prediction of efavirenz plasma concentrations from CYP2B6 and CYP2A6 genotypes.

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