Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma by Raby Benjamin A, Van Steen Kristel, Lasky-Su Jessica, Tantisira Kelan, Kaplan Feige, Weiss Scott T in Respiratory research (2009).

[PMID: 19619331] PubMed


Glucocorticoid function is dependent on efficient translocation of the glucocorticoid receptor (GR) from the cytoplasm to the nucleus of cells. Importin-13 (IPO13) is a nuclear transport receptor that mediates nuclear entry of GR. In airway epithelial cells, inhibition of IPO13 expression prevents nuclear entry of GR and abrogates anti-inflammatory effects of glucocorticoids. Impaired nuclear entry of GR has been documented in steroid-non-responsive asthmatics. We hypothesize that common IPO13 genetic variation influences the anti-inflammatory effects of inhaled corticosteroids for the treatment of asthma, as measured by change in methacholine airway hyperresponsiveness (AHR-PC20).

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