Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect by Caselli Richard J, Dueck Amylou C, Osborne David, Sabbagh Marwan N, Connor Donald J, Ahern Geoffrey L, Baxter Leslie C, Rapcsak Steven Z, Shi Jiong, Woodruff Bryan K, Locke Dona E C, Snyder Charlene Hoffman, Alexander Gene E, Rademakers Rosa, Reiman Eric M in The New England journal of medicine (2009).

[PMID: 19605830] PubMed


The APOE epsilon4 allele is associated with the risk of late-onset Alzheimer's disease. The age at which memory decline diverges among persons who are homozygous for the APOE epsilon4 allele, those who are heterozygous for the allele, and noncarriers is unknown.

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