Acquired resistance to gefitinib: the contribution of mechanisms other than the T790M, MET, and HGF status by Onitsuka Takamitsu, Uramoto Hidetaka, Nose Naohiro, Takenoyama Mitsuhiro, Hanagiri Takeshi, Sugio Kenji, Yasumoto Kosei in Lung cancer (Amsterdam, Netherlands) (2010).

[PMID: 19589612] PubMed


Some types of somatic mutation of the epidermal growth factor receptor (EGFR) gene in non-small cell lung cancer (NSCLC) are associated with a significant clinical response to a tyrosine kinase inhibitor (TKI). However, most of the patients with this type of sensitive mutations in their tumor show acquired resistance during the TKI treatment.

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