Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthma by Corvol Harriet, De Giacomo Anthony, Eng Celeste, Seibold Max, Ziv Elad, Chapela Rocio, Rodriguez-Santana Jose R, Rodriguez-Cintron William, Thyne Shannon, Watson H Geoffrey, Meade Kelley, LeNoir Michael, Avila Pedro C, Choudhry Shweta, Burchard Esteban González, Genetics of Asthma in Latino Americans (GALA) Study, Study of African-Americans, Asthma, Genes and Environments (SAGE) Investigators in Pharmacogenetics and genomics (2009).

[PMID: 19503017] PubMed


A recent admixture mapping analysis identified interleukin 6 (IL6) and IL6 receptor (IL6R) as candidate genes for inflammatory diseases. In the airways during allergic inflammation, IL6 signaling controls the production of proinflammatory and anti-inflammatory factors. In addition, albuterol, a commonly prescribed asthma therapy, has been shown to influence IL6 gene expression. Therefore, we reasoned that interactions between the IL6 and IL6R genes might be associated with bronchodilator drug responsiveness to albuterol in asthmatic patients.

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