Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants by Hirschfield Gideon M, Liu Xiangdong, Xu Chun, Lu Yue, Xie Gang, Lu Yan, Gu Xiangjun, Walker Erin J, Jing Kaiyan, Juran Brian D, Mason Andrew L, Myers Robert P, Peltekian Kevork M, Ghent Cameron N, Coltescu Catalina, Atkinson Elizabeth J, Heathcote E Jenny, Lazaridis Konstantinos N, Amos Christopher I, Siminovitch Katherine A in The New England journal of medicine (2009).

[PMID: 19458352] PubMed


Primary biliary cirrhosis is a chronic granulomatous cholangitis, characteristically associated with antimitochondrial antibodies. Twin and family aggregation data suggest that there is a significant genetic predisposition to primary biliary cirrhosis, but the susceptibility loci are unknown.

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