DNA repair gene polymorphisms predict favorable clinical outcome in advanced non-small-cell lung cancer by Kalikaki Aristea, Kanaki Maria, Vassalou Helen, Souglakos John, Voutsina Alexandra, Georgoulias Vassilis, Mavroudis Dimitris in Clinical lung cancer (2009).

[PMID: 19362955] PubMed

Abstract

Genetic polymorphisms of genes involved in DNA repair and glutathione metabolic pathways may affect patients' response to platinum-based chemotherapy. We retrospectively assessed whether single nucleotide polymorphisms (SNP) of DNA-repair genes ERCC1, XPD, XRCC1 and glutathione S-transferase genes GSTP1, GSTT1 and GSTM1 predict overall survival (OS), response and toxicity in 119 non-small-cell lung cancer (NSCLC) patients treated with platinum-based regimens as first- or second-line chemotherapy.

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