Assessing the reproducibility of asthma candidate gene associations, using genome-wide data by Rogers Angela J, Raby Benjamin A, Lasky-Su Jessica A, Murphy Amy, Lazarus Ross, Klanderman Barbara J, Sylvia Jody S, Ziniti John P, Lange Christoph, Celedón Juan C, Silverman Edwin K, Weiss Scott T in American journal of respiratory and critical care medicine (2009).

[PMID: 19264973] PubMed


Association studies have implicated many genes in asthma pathogenesis, with replicated associations between single-nucleotide polymorphisms (SNPs) and asthma reported for more than 30 genes. Genome-wide genotyping enables simultaneous evaluation of most of this variation, and facilitates more comprehensive analysis of other common genetic variation around these candidate genes for association with asthma.

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