IDH1 and IDH2 mutations in gliomas by Yan Hai, Parsons D Williams, Jin Genglin, McLendon Roger, Rasheed B Ahmed, Yuan Weishi, Kos Ivan, Batinic-Haberle Ines, Jones Sin, Riggins Gregory J, Friedman Henry, Friedman Allan, Reardon David, Herndon James, Kinzler Kenneth W, Velculescu Victor E, Vogelstein Bert, Bigner Darell D in The New England journal of medicine (2009).

[PMID: 19228619] PubMed


A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase 1 gene (IDH1) in a fraction of such tumors, most frequently in tumors that were known to have evolved from lower-grade gliomas (secondary glioblastomas).

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