Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia by Mullighan Charles G, Su Xiaoping, Zhang Jinghui, Radtke Ina, Phillips Letha A A, Miller Christopher B, Ma Jing, Liu Wei, Cheng Cheng, Schulman Brenda A, Harvey Richard C, Chen I-Ming, Clifford Robert J, Carroll William L, Reaman Gregory, Bowman W Paul, Devidas Meenakshi, Gerhard Daniela S, Yang Wenjian, Relling Mary V, Shurtleff Sheila A, Campana Dario, Borowitz Michael J, Pui Ching-Hon, Smith Malcolm, Hunger Stephen P, Willman Cheryl L, Downing James R, Children's Oncology Group in The New England journal of medicine (2009). PubMed


Despite best current therapy, up to 20% of pediatric patients with acute lymphoblastic leukemia (ALL) have a relapse. Recent genomewide analyses have identified a high frequency of DNA copy-number abnormalities in ALL, but the prognostic implications of these abnormalities have not been defined.

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