Shared and distinct genetic variants in type 1 diabetes and celiac disease by Smyth Deborah J, Plagnol Vincent, Walker Neil M, Cooper Jason D, Downes Kate, Yang Jennie H M, Howson Joanna M M, Stevens Helen, McManus Ross, Wijmenga Cisca, Heap Graham A, Dubois Patrick C, Clayton David G, Hunt Karen A, van Heel David A, Todd John A in The New England journal of medicine (2008).

[PMID: 19073967] PubMed


Two inflammatory disorders, type 1 diabetes and celiac disease, cosegregate in populations, suggesting a common genetic origin. Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shared.

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