Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci by Cooper Jason D, Smyth Deborah J, Smiles Adam M, Plagnol Vincent, Walker Neil M, Allen James E, Downes Kate, Barrett Jeffrey C, Healy Barry C, Mychaleckyj Josyf C, Warram James H, Todd John A in Nature genetics (2008).

[PMID: 18978792] PubMed


We carried out a meta-analysis of data from three genome-wide association (GWA) studies of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of European ancestry. We obtained further support for 4q27 (IL2-IL21, P = 1.9 x 10(-8)) and, after genotyping an additional 6,225 cases, 6,946 controls and 2,828 families, convincing evidence for four previously unknown and distinct risk loci in chromosome regions 6q15 (BACH2, P = 4.7 x 10(-12)), 10p15 (PRKCQ, P = 3.7 x 10(-9)), 15q24 (CTSH, P = 3.2 x 10(-15)) and 22q13 (C1QTNF6, P = 2.0 x 10(-8)).

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