VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans by Limdi Nita A, Beasley T Mark, Crowley Michael R, Goldstein Joyce A, Rieder Mark J, Flockhart David A, Arnett Donna K, Acton Ronald T, Liu Nianjun in Pharmacogenomics (2008).

[PMID: 18855533] PubMed


Although the influence of VKORC1 and CYP2C9 polymorphisms on warfarin response has been studied, variability in dose explained by CYP2C9 and VKORC1 is lower among African-Americans compared with European-Americans. This has lead investigators to hypothesize that assessment of VKORC1 haplotypes may help capture a greater proportion of the variability in dose for this under-represented group. However, the inadequate representation of African-Americans and the assessment of a few VKORC1 polymorphisms have hindered this effort.

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