Functional polymorphisms in the BRCA1 promoter influence transcription and are associated with decreased risk for breast cancer in Chinese women by Chan K Y-K, Liu W, Long J-R, Yip S-P, Chan S-Y, Shu X-O, Chua D T-T, Cheung A N-Y, Ching J C-Y, Cai H, Au G K-H, Chan M, Foo W, Ngan H Y-S, Gao Y-T, Ngan E S-W, Garcia-Barceló M-M, Zheng Wei, Khoo U-S in Journal of medical genetics (2009). PubMed


The BRCA1 gene is an important breast-cancer susceptibility gene. Promoter polymorphisms can alter the binding affinity of transcription factors, changing transcriptional activity and may affect susceptibility to disease.

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