Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12 by Sun Jielin, Zheng Siqun Lilly, Wiklund Fredrik, Isaacs Sarah D, Purcell Lina D, Gao Zhengrong, Hsu Fang-Chi, Kim Seong-Tae, Liu Wennuan, Zhu Yi, Stattin Pär, Adami Hans-Olov, Wiley Kathleen E, Dimitrov Latchezar, Sun Jishan, Li Tao, Turner Aubrey R, Adams Tamara S, Adolfsson Jan, Johansson Jan-Erik, Lowey James, Trock Bruce J, Partin Alan W, Walsh Patrick C, Trent Jeffrey M, Duggan David, Carpten John, Chang Bao-Li, Grönberg Henrik, Isaacs William B, Xu Jianfeng in Nature genetics (2008).

[PMID: 18758462] PubMed


We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, approximately 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 x 10(-9) for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.

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