Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population by Locharernkul Chaichon, Loplumlert Jakrin, Limotai Chusak, Korkij Wiwat, Desudchit Tayard, Tongkobpetch Siraprapa, Kangwanshiratada Oratai, Hirankarn Nattiya, Suphapeetiporn Kanya, Shotelersuk Vorasuk in Epilepsia (2008). PubMed


Previous studies found a strong association between HLA-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) in Han Chinese, but not in Caucasian populations. Even in Han Chinese, the HLA-B*1502 was not associated with CBZ-induced maculopapular eruptions (MPE). This study seeks to identify whether HLA-B*1502 is associated with CBZ- or phenytoin (PHT)-induced SJS or MPE in a Thai population.

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