Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population by Locharernkul Chaichon, Loplumlert Jakrin, Limotai Chusak, Korkij Wiwat, Desudchit Tayard, Tongkobpetch Siraprapa, Kangwanshiratada Oratai, Hirankarn Nattiya, Suphapeetiporn Kanya, Shotelersuk Vorasuk in Epilepsia (2008).

[PMID: 18637831] PubMed


Previous studies found a strong association between HLA-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) in Han Chinese, but not in Caucasian populations. Even in Han Chinese, the HLA-B*1502 was not associated with CBZ-induced maculopapular eruptions (MPE). This study seeks to identify whether HLA-B*1502 is associated with CBZ- or phenytoin (PHT)-induced SJS or MPE in a Thai population.

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