Detection of mutations in EGFR in circulating lung-cancer cells by Maheswaran Shyamala, Sequist Lecia V, Nagrath Sunitha, Ulkus Lindsey, Brannigan Brian, Collura Chey V, Inserra Elizabeth, Diederichs Sven, Iafrate A John, Bell Daphne W, Digumarthy Subba, Muzikansky Alona, Irimia Daniel, Settleman Jeffrey, Tompkins Ronald G, Lynch Thomas J, Toner Mehmet, Haber Daniel A in The New England journal of medicine (2008).

[PMID: 18596266] PubMed


The use of tyrosine kinase inhibitors to target the epidermal growth factor receptor gene (EGFR) in patients with non-small-cell lung cancer is effective but limited by the emergence of drug-resistance mutations. Molecular characterization of circulating tumor cells may provide a strategy for noninvasive serial monitoring of tumor genotypes during treatment.

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