BDNF gene is a genetic risk factor for schizophrenia and is related to the chlorpromazine-induced extrapyramidal syndrome in the Chinese population by Xu Ming-Qing, St Clair David, Feng Guo-Yin, Lin Zhi-Guang, He Guang, Li Xingwang, He Lin in Pharmacogenetics and genomics (2008).

[PMID: 18408624] PubMed


Brain-derived neurotrophic factor (BDNF) belongs to a family of the neurotrophin, which plays important roles in the neurodevelopment of dopaminergic-related systems and interacts with meso-limbic dopaminergic systems involved in the therapeutic response to antipsychotics. Functional experiments have suggested that BDNF may be involved in the etiology of schizophrenia.

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