Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function by Ober Carole, Tan Zheng, Sun Ying, Possick Jennifer D, Pan Lin, Nicolae Raluca, Radford Sadie, Parry Rodney R, Heinzmann Andrea, Deichmann Klaus A, Lester Lucille A, Gern James E, Lemanske Robert F, Nicolae Dan L, Elias Jack A, Chupp Geoffrey L in The New England journal of medicine (2008).

[PMID: 18403759] PubMed


The chitinase-like protein YKL-40 is involved in inflammation and tissue remodeling. We recently showed that serum YKL-40 levels were elevated in patients with asthma and were correlated with severity, thickening of the subepithelial basement membrane, and pulmonary function. We hypothesized that single-nucleotide polymorphisms (SNPs) that affect YKL-40 levels also influence asthma status and lung function.

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