Treatment of patients with the hypereosinophilic syndrome with mepolizumab by Rothenberg Marc E, Klion Amy D, Roufosse Florence E, Kahn Jean Emmanuel, Weller Peter F, Simon Hans-Uwe, Schwartz Lawrence B, Rosenwasser Lanny J, Ring Johannes, Griffin Elaine F, Haig Ann E, Frewer Paul I H, Parkin Jacqueline M, Gleich Gerald J, Mepolizumab HES Study Group in The New England journal of medicine (2008).

[PMID: 18344568] PubMed


The hypereosinophilic syndrome is a group of diseases characterized by persistent blood eosinophilia, defined as more than 1500 cells per microliter with end-organ involvement and no recognized secondary cause. Although most patients have a response to corticosteroids, side effects are common and can lead to considerable morbidity.

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