Vasopressin versus norepinephrine infusion in patients with septic shock by Russell James A, Walley Keith R, Singer Joel, Gordon Anthony C, H├ębert Paul C, Cooper D James, Holmes Cheryl L, Mehta Sangeeta, Granton John T, Storms Michelle M, Cook Deborah J, Presneill Jeffrey J, Ayers Dieter, VASST Investigators in The New England journal of medicine (2008). PubMed


Vasopressin is commonly used as an adjunct to catecholamines to support blood pressure in refractory septic shock, but its effect on mortality is unknown. We hypothesized that low-dose vasopressin as compared with norepinephrine would decrease mortality among patients with septic shock who were being treated with conventional (catecholamine) vasopressors.

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