The non-synonymous coding IKr-channel variant KCNH2-K897T is associated with atrial fibrillation: results from a systematic candidate gene-based analysis of KCNH2 (HERG) by Sinner Moritz F, Pfeufer Arne, Akyol Mahmut, Beckmann Britt-Maria, Hinterseer Martin, Wacker Annette, Perz Siegfried, Sauter Wiebke, Illig Thomas, Näbauer Michael, Schmitt Claus, Wichmann H-Erich, Schömig Albert, Steinbeck Gerhard, Meitinger Thomas, Kääb Stefan in European heart journal (2008).

[PMID: 18222980] PubMed


Atrial fibrillation (AF) is the most frequent arrhythmia in humans. Rare familial forms exist. Recent evidence indicates a genetic susceptibility to common forms of AF. The alpha-subunit of the myocardial I(Kr)-channel, encoded by the KCNH2 gene, is crucial to ventricular and atrial repolarization. Patients with mutations in KCNH2 present with higher incidence of AF. Common variants in KCNH2 have been shown to modify ventricular repolarization. We intended to investigate, whether such variants may also modulate atrial repolarization and predispose to AF.

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