Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX by Hom Geoffrey, Graham Robert R, Modrek Barmak, Taylor Kimberly E, Ortmann Ward, Garnier Sophie, Lee Annette T, Chung Sharon A, Ferreira Ricardo C, Pant P V Krishna, Ballinger Dennis G, Kosoy Roman, Demirci F Yesim, Kamboh M Ilyas, Kao Amy H, Tian Chao, Gunnarsson Iva, Bengtsson Anders A, Rantapää-Dahlqvist Solbritt, Petri Michelle, Manzi Susan, Seldin Michael F, Rönnblom Lars, Syvänen Ann-Christine, Criswell Lindsey A, Gregersen Peter K, Behrens Timothy W in The New England journal of medicine (2008).

[PMID: 18204098] PubMed


Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in which the risk of disease is influenced by complex genetic and environmental contributions. Alleles of HLA-DRB1, IRF5, and STAT4 are established susceptibility genes; there is strong evidence for the existence of additional risk loci.

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