Psoriasis is associated with increased beta-defensin genomic copy number by Hollox Edward J, Huffmeier Ulrike, Zeeuwen Patrick L J M, Palla Raquel, Lascorz Jesús, Rodijk-Olthuis Diana, van de Kerkhof Peter C M, Traupe Heiko, de Jongh Gys, den Heijer Martin, Reis André, Armour John A L, Schalkwijk Joost in Nature genetics (2008).

[PMID: 18059266] PubMed


Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis.

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