Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1 by Faraday Nauder, Yanek Lisa R, Mathias Rasika, Herrera-Galeano J Enrique, Vaidya Dhananjay, Moy Taryn F, Fallin M Daniele, Wilson Alexander F, Bray Paul F, Becker Lewis C, Becker Diane M in Circulation (2007).

[PMID: 17470694] PubMed


The inability of aspirin (acetylsalicylic acid [ASA]) to adequately suppress platelet function is associated with future risk of myocardial infarction, stroke, and cardiovascular death. Genetic variation is a proposed but unproved mechanism for insufficient ASA responsiveness.

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