Interleukin-1-receptor antagonist in type 2 diabetes mellitus by Larsen Claus M, Faulenbach Mirjam, Vaag Allan, Vølund Aage, Ehses Jan A, Seifert Burkhardt, Mandrup-Poulsen Thomas, Donath Marc Y in The New England journal of medicine (2007).

[PMID: 17429083] PubMed


The expression of interleukin-1-receptor antagonist is reduced in pancreatic islets of patients with type 2 diabetes mellitus, and high glucose concentrations induce the production of interleukin-1beta in human pancreatic beta cells, leading to impaired insulin secretion, decreased cell proliferation, and apoptosis.

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