Increased risk of incident stroke associated with the cyclooxygenase 2 (COX-2) G-765C polymorphism in African-Americans: the Atherosclerosis Risk in Communities Study by Kohsaka Shun, Volcik Kelly A, Folsom Aaron R, Wu Kenneth K, Ballantyne Christie M, Willerson James T, Boerwinkle Eric in Atherosclerosis (2008). PubMed


A hallmark feature of atherosclerosis is inflammation mediated by prostaglandins (PGs) catalyzed by the enzyme cyclooxygenase (COX). The present study explored whether the COX-2 G-765C polymorphism contributes to increased incidence of coronary heart disease (CHD) or stroke in the large prospective Atherosclerosis Risk in Communities (ARIC) Study.

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