Comment on "A common genetic variant is associated with adult and childhood obesity" by Dina Christian, Meyre David, Samson Chantal, Tichet Jean, Marre Michel, Jouret Beatrice, Charles Marie Aline, Balkau Beverley, Froguel Philippe in Science (New York, N.Y.) (2007).

[PMID: 17218508] PubMed


Herbert et al. (Reports, 14 April 2006, p. 279) reported an association between the INSIG2 gene variant rs7566605 and obesity in four sample populations, under a recessive model. We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity.

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