ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals by Coller Janet K, Barratt Daniel T, Dahlen Karianne, Loennechen Morten H, Somogyi Andrew A in Clinical pharmacology and therapeutics (2006).

[PMID: 17178268] PubMed


The most common treatment for opioid dependence is substitution therapy with another opioid such as methadone. The methadone dosage is individualized but highly variable, and program retention rates are low due in part to nonoptimal dosing resulting in withdrawal symptoms and further heroin craving and use. Methadone is a substrate for the P-glycoprotein transporter, encoded by the ABCB1 gene, which regulates central nervous system exposure. This retrospective study aimed to investigate the influence of ABCB1 genetic variability on methadone dose requirements.

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