ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment
Eap Chin B
Clinical pharmacology and therapeutics (2006).
The in vivo implication of various cytochrome P450 (CYP) isoforms and of P-glycoprotein on methadone kinetics is unclear. We aimed to thoroughly examine the genetic factors influencing methadone kinetics and response to treatment.