Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis by Wessels Judith A M, Kooloos Wouter M, De Jonge Robert, De Vries-Bouwstra Jeska K, Allaart Cornelia F, Linssen Annelies, Collee Gerard, De Sonnaville Peter, Lindemans Jan, Huizinga Tom W J, Guchelaar Henk-Jan in Arthritis and rheumatism (2006).

[PMID: 16947783] PubMed


Among patients with rheumatoid arthritis (RA), there is a high degree of interindividual variability in the degree of response to methotrexate (MTX) treatment. This study was undertaken to explore polymorphisms in genes contributing to antiinflammatory adenosine release as novel predictors of MTX treatment outcome.

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